Stanford Society of
Physician Scholars  

Aggie Janisiewicz MD


Resident, Stanford Department of Otolaryngology

Education:
Undergraduate: Harvard College
Medical School: Harvard Medical School

Current research focus: I am interested in understanding cancer stem cell biology and how it applies to nasopharyngeal carcinoma (NPC). Nasopharyngeal carcinoma is the only head and neck cancer that does not have a universally accepted staging system and is remarkably aggressive upon recurrent (typically <40% survivial at 2.5 years after recurrence). Hence it is necessary to 1) refine our staging system and 2) throughly understand which cancers need to be treated more aggressively to prevent recurrence. Cancer stem cell have been shown in other malignancies (breast and head neck SCC) to likely be the treatment resistant, malignancy initaiating population of cells. By studying this concept in NPC we hope to address both points and change patient care alogrithms.

Opportunities to work with Dr. Aggie Janisiewicz: I welcome both medical and undergraduate students to work with me on my research.

Contact: ajanis@stanford.edu

Publications:

1. Kantor S, Mochizuki T, Janisiewicz AM, Clark E, Nishino S, Scammell TE. "Orexin neurons are necessary for the circadian control of REM sleep. " Sleep. 2009 Sep 1;32(9):1127-34. PMID: 19750917 [PubMed - indexed for MEDLINE]

2. Si K., Giustetto M., Etkin A., Hsu R., Janisiewicz A.M., Zhu H., and Eric R Kandel (2003). A Neuronal Isoform of CPEB Regulates Local Protein Synthesis and Stabilizes Synapse-Specific Long-Term Facilitation in Aplysia. Cell. 26 Dec; 115: 893-904.

3. Janisiewicz A.M., Jackson O., Firoz E.F. and Baxter M.G. (2004) Environment-spatial conditional learning in rats with selective lesions of the medial septal cholinergic neurons. Hippocampus, 14:2, 265-273.

4. Janisiewicz AM and Baxter MG. (2003) Transfer Effects and Conditional Learning in Rats with Selective Lesions of Medial Septal/ Diagonal Band Cholinergic Neurons. Behavioral Neuroscience, 117, 1342-1352.

 

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